Due terzi compiuti

Pensieri e esperienze di un’anatra selvaggia di ottanta e un anni.

Avram Miller by the sea
EN | IT

587 post pubblicati dal 2006

Tag: Health Span

  • Longevità nei quarantenni

    A new friend in Lecce recently asked me for advice about longevity. He was surprised by what he perceived as my relative youth. Others who know that I’ve worked in the field of longevity for years sometimes ask for my “secret.”

    I usually joke that the secret was choosing the right parents.

    That joke is partly true. Genetics matte, but they may account for only about 20–30% of lifespan. However a recent studies indicate it may be more like 50%( https://www.rnz.co.nz/news/world/585445/greater-role-for-genetics-in-driving-human-lifespan-study-finds). The rest is something far more actionable.

    Genetics Set the Ceiling but how You Live Determines the Outcome

    I believe genetics determines your maximum potential lifespan. In that respect, I did win the lottery.

    My father lived to 97 and remained in excellent physical condition, working out six days a week until he was 95. Had he treated his brain like a muscle as well, he might have avoided the dementia that appeared late in life. My mother, sadly, died young at 67 by taking her own life but her mother lived to 94 and her mother’s mother to 98.

    So while genetics may define the ceiling, everything you do during your life subtracts from it.

    Smoking at 20 may shave a decade off your lifespan. Chronic sleep deprivation quietly steals years. Poor metabolic health doesn’t announce itself early—it slowly gnaws away at your longevity. Longevity is less about adding years than about not losing them unnecessarily.

    (altro…)
  • Are We As Old As Our Oldest Part?

    As readers of my blog know, I’m deeply interested in longevity. I helped establish the Longevity Center at Sheba Hospital (Tel Aviv University) in Israel, which I continue to advise. My interest spans both the biological science of aging and the economic implications of a world where more people live longer—potentially requiring support from a shrinking working-age population.

    At 80, my curiosity about aging is also very personal.

    I believe I’d be considered a super-ager, both mentally and physically. I’ve worked hard at this—regular exercise (physical and cognitive), a healthy diet, weight control, strong social engagement, and good sleep habits. I also closely monitor my body through regular lab tests and scans.

    Am I losing my senses

    While my mind and body remain strong, my senses are showing signs of age.

    My hearing and vision have both diminished. I’ve resisted hearing aids (yes, vanity), though AirPods help in certain settings. My eyesight can no longer be corrected to 20/20. My right eye in particular is weak; I can’t read with it alone. Tests confirmed a cataract is to blame. I’ve had OCT imaging and other diagnostics—everything looks stable, but my eyes are simply getting old.

    I’ve chosen to delay cataract surgery for now. I still see well with both eyes, and glasses have been part of my life since age 7—they’re part of my image. I’ve spoken to several people who regret their lens replacements. The risks feel unnecessary for now.

    Maybe I’ll wait for AI glasses that help both hearing and sight.

    That’s the big question I keep coming back to: Are we as old as our oldest part?

    I see vibrant people struggling with hips, knees, or memory. Dementia becomes a real concern after 80—about 25–30% of people in their 80s have it, and that number climbs to almost 50% in their 90s. My father, incredibly fit and sharp into his 80s, developed dementia in his 90s. He passed away at 97.

    We may conquer cancer, heart disease, and neurodegeneration, but the slow decay of joints or senses can still gut our quality of life.

    What the Billionaire Longevity  Boys Club Is Doing

    Many wealthy entrepreneurs are investing in longevity. If I had billions, I might do the same. They’re chasing breakthroughs—some realistic, some radical.

    Here are the key figures and what they’re doing:

    NameLongevity GoalApproach / MethodsCompanies / Projects
    Jeff BezosReverse aging, extend lifespanBiotech R&D on cellular reprogrammingAltos Labs, Unity Biotechnology
    Bryan JohnsonAchieve biologically younger body & brainIntensive self-tracking and data-driven protocolBlueprint (his own project)
    Peter ThielRadical life extension, possible immortalitySenolytics, parabiosis, cryonicsUnity Biotechnology, Alcor, Methuselah Foundation
    Larry EllisonDefeat aging as a diseaseLarge-scale research fundingEllison Medical Foundation
    Sergey BrinDelay aging, prevent age-related diseaseAI + biology, deep science R&DCalico Labs
    Larry PageAdd decades of healthy lifeBiotech moonshotsCalico Labs
    Elon MuskExtend brain and human potentialBrain-machine interface (not focused on aging per se)Neuralink
    Sam AltmanAdd 10+ years of healthy life for allReprogramming, immune rejuvenationRetro Biosciences
    Christian AngermayerExtend life, enhance mental and physical healthPsychedelics, cellular therapy, biotech investingRejuveron, Cambrian Biopharma, Atai
    Tony RobbinsStay youthful and energetic as he agesSupplements, stem cells, wellness advocacyLife Force (book), various investments

    I admire their ambition. I hope they succeed. But even if we conquer the “big three”—heart disease, dementia, and cancer—we may still be limited by the parts that wear out first.

    In the end, maybe we are just as old as our oldest part. I hope not.

  • Winding Down, Winding Up or Just Winding-The Next Ten Years of my Life 

    When I was diagnosed and treated for prostate cancer in 1996, I made a decision that changed my life forever. Prostate cancer is slow growing, and if the treatment did not work, I would still have at least ten more years to live. In my case, it appeared that the cancer had metastasized (it had not). So I decided to live my life as if I only had ten more years. This happened at a time when my friend, Dave Roux—who was then responsible for Corporate Development and M&A at Oracle and I were working together to create a leveraged buyout firm.

    Having made the decision to live as if I only had ten years, I realized I did not want to spend those years running a private equity firm, and I told that to Dave. He went on to create Silverlake, which became a very successful firm. In the process, he became a billionaire. I assume I would have as well. By the way, Dave is a really good person. His family foundation supports many important projects.

    I took a different path—one that I do not regret. It was no longer tied to any organization and not driven by financial concerns.

    I thought at the time that ten years was long enough to accomplish something like learning a new language, developing new skills, or having a deep and meaningful relationship—but short enough to feel some urgency. Thinking that you only have ten years to live could be considered pessimistic. But now, at the age of 80, I think it is an optimistic way to consider the future.

    I struggle with my age, and I have written about that in this blog. Sometimes I wake up in shock when I realize how old I have become. While about 60% of men live to 80, only about 10% are in excellent health (I appear to be one of those). Ten years later, only about 5% of men are still alive—and those who are, are overwhelmingly in poor health. 

    While I have a good chance of making it to 90, it is not just a question of life span. Health span is the critical question. While I wrote that I am in excellent health, I am starting to notice a decline in my hearing and sight. I wonder, are we as old as our oldest part? I hope not.

    We had left Israel just before October 7, 2023, on a combination vacation and business trip. Having already decided to move from Israel in 2025, we accelerated that decision. I loved living in Israel, but the Israel I had loved was no more. We needed to create a new life. 

    We ended up moving to Amsterdam, where I was engaged in work related to AI and cancer diagnosis. It felt like a rest stop in what had become a very confusing world—still in motion, but catching our breath. Eventually, we chose Italy. I had always said jokingly that in my next life, I’d come back as an Italian—and then I thought, why wait?

    But my 80th birthday weighed heavily on me. I struggled to imagine my future. We desperately wanted to settle into our own home. I missed my piano, which was still sitting in storage in San Francisco. The piano I had in Tel Aviv was sold with that house. We missed our art and the small things that my wife and I had collected over our years together.

    The question of how to use the ten years—likely the last ten years—came into sharper focus recently, as we made a major life decision: we would put down our roots in Italy.

    My anxiety about the future came to a head when we decided to buy a home in Lecce, Italy. I tried to imagine my life living in this city at this age and over the next ten years. It was then that I realized the decision to live as if I only had ten years was no longer a pessimistic view but an optimistic one, and I decided to embrace that optimism. We will live in Lecce in a beautiful palazzo in the heart of the historic center. Lecce is called the Florence of the South. It is a Baroque city located less than 30 minutes from amazing beaches on both the Adriatic and Ionian seas.

    It will be almost essential for me to learn Italian. I am struggling with that. This is the third language I’ve had to learn after English but I am committed to doing it.

    One reason to remain optimistic is the progress I expect we will see in health care because of AI. I am watching this closely and am personally involved in the field as an advisor to the Longevity Center at Sheba Hospital in Israel. I have started to get involved in longevity research in Italy as well. I still want to engage in creating the future and believe I have much to offer. I want not only to live longer and better—but to help others do that as well.

    So whether I am winding down, winding up, or just winding my way through this next chapter, I know one thing for certain: I’m still moving forward—with curiosity, with purpose,  hope and a song in my soul.

  • Living longer better

    I have not given this blog much attention since I started writing my book, The Flight of a Wild Duck, four years ago. It was published in September of 2021. I have a lot more that I want to write, but frankly, the effort of writing a 340-page book dampened my enthusiasm for writing. Now I compose posts in my head, but they seldom make it to the screen (I can’t say paper anymore). On the other hand, the response from the few that read my book has been overwhelmingly good. I wish more people would read it (including you if you have not already read it). You can order it here.

    Many of you will know (especially those that read the book) that I started my professional career doing medical science. 

    First, I was at Langley Porter-UCSF Medical School, where I developed the first EEG Biofeedback technology. Then I was one of the founders of the Thoraxcenter, Erasmus University, where I led the computer department, which created the first Catheterization Labs Computer Systems, as well as one of the first ICU monitoring systems. Later, I was an associate professor at Tel Aviv University in the Department of Cardiology, the first time I lived in Israel.  

    For the last ten years, I have slowly found myself back in medical technology as an advisor and investor. Here are the companies I worked/work with.

    www.sommetrics.com sleep apnea

    www.ouraring.com  sleep wearable sold my position major gain

    www.ensodata.com sleep test AI

    www.nutrino.com  nutrition sold to Medtronic major gain

    www.wisdo.com loneliness 

    www.innovega.com sight

    www.amulet-inc.com/ food allergies

    Now that I am really looking into this, I am pretty sure I will find some great investment opportunities. But more importantly, I might be able to do something that matters, once again.

    Also about five years ago, I became an advisor to the Executive Director of the Cleveland Clinic’s Research Institute.

    But frankly, other than Sommetrics, I was not that involved.  

    Lately, maybe because I am now 77 years old, I became interested in longevity or better said, increase health span. I became an advisor to Sheba Hospital, Israel’s largest and one of the top ten hospitals in the world. I am helping them set up a center for longevity. One of my roles is looking at early stage companies. I am learning a lot about what is called precision medicine. I am also learning about how screwed up a current way of treating people is.  

    So you might expect to have some blog posts on what I am learning and what I am thinking in the topic of increasing health span.