As readers of my blog know, I’m deeply interested in longevity. I helped establish the Longevity Center at Sheba Hospital (Tel Aviv University) in Israel, which I continue to advise. My interest spans both the biological science of aging and the economic implications of a world where more people live longer—potentially requiring support from a shrinking working-age population.
At 80, my curiosity about aging is also very personal.
I believe I’d be considered a super-ager, both mentally and physically. I’ve worked hard at this—regular exercise (physical and cognitive), a healthy diet, weight control, strong social engagement, and good sleep habits. I also closely monitor my body through regular lab tests and scans.
Am I losing my senses
While my mind and body remain strong, my senses are showing signs of age.
My hearing and vision have both diminished. I’ve resisted hearing aids (yes, vanity), though AirPods help in certain settings. My eyesight can no longer be corrected to 20/20. My right eye in particular is weak; I can’t read with it alone. Tests confirmed a cataract is to blame. I’ve had OCT imaging and other diagnostics—everything looks stable, but my eyes are simply getting old.
I’ve chosen to delay cataract surgery for now. I still see well with both eyes, and glasses have been part of my life since age 7—they’re part of my image. I’ve spoken to several people who regret their lens replacements. The risks feel unnecessary for now.
Maybe I’ll wait for AI glasses that help both hearing and sight.
That’s the big question I keep coming back to: Are we as old as our oldest part?
I see vibrant people struggling with hips, knees, or memory. Dementia becomes a real concern after 80—about 25–30% of people in their 80s have it, and that number climbs to almost 50% in their 90s. My father, incredibly fit and sharp into his 80s, developed dementia in his 90s. He passed away at 97.
We may conquer cancer, heart disease, and neurodegeneration, but the slow decay of joints or senses can still gut our quality of life.
What the Billionaire Longevity Boys Club Is Doing
Many wealthy entrepreneurs are investing in longevity. If I had billions, I might do the same. They’re chasing breakthroughs—some realistic, some radical.
Here are the key figures and what they’re doing:
| Name | Longevity Goal | Approach / Methods | Companies / Projects |
| Jeff Bezos | Reverse aging, extend lifespan | Biotech R&D on cellular reprogramming | Altos Labs, Unity Biotechnology |
| Bryan Johnson | Achieve biologically younger body & brain | Intensive self-tracking and data-driven protocol | Blueprint (his own project) |
| Peter Thiel | Radical life extension, possible immortality | Senolytics, parabiosis, cryonics | Unity Biotechnology, Alcor, Methuselah Foundation |
| Larry Ellison | Defeat aging as a disease | Large-scale research funding | Ellison Medical Foundation |
| Sergey Brin | Delay aging, prevent age-related disease | AI + biology, deep science R&D | Calico Labs |
| Larry Page | Add decades of healthy life | Biotech moonshots | Calico Labs |
| Elon Musk | Extend brain and human potential | Brain-machine interface (not focused on aging per se) | Neuralink |
| Sam Altman | Add 10+ years of healthy life for all | Reprogramming, immune rejuvenation | Retro Biosciences |
| Christian Angermayer | Extend life, enhance mental and physical health | Psychedelics, cellular therapy, biotech investing | Rejuveron, Cambrian Biopharma, Atai |
| Tony Robbins | Stay youthful and energetic as he ages | Supplements, stem cells, wellness advocacy | Life Force (book), various investments |
I admire their ambition. I hope they succeed. But even if we conquer the “big three”—heart disease, dementia, and cancer—we may still be limited by the parts that wear out first.
In the end, maybe we are just as old as our oldest part. I hope not.
Hey Avram, lots of stuff happening in this space! If you want to learn more about Celljevity please reach out!
All the Best, Diederik
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I am not a fan of supplements. Sorry!
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We don’t sell supplements! Perhaps you went on the website of Cellgevity…
Please have a look at http://www.celljevity.life
We are leading the field in cellular reprogramming and my partner Yi Eve Sun is a UCLA professor and one of the leading stem cell researchers globally 🙂
Best, Didi
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I did. Maybe next time you may want to leave a link. I will check your site tomorrow. It is getting a bit late in Genoa.
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